VMAT2 binding was found to be increased in one study of people with bipolar mania. In diagnosis, caregiver-scored rating scales, specifically the mother, has been found to be more accurate than teacher and youth report in predicting identifying youths with bipolar disorder.
The ICD criteria are used more often in clinical settings outside of the U. Several rating scales for the screening and evaluation of bipolar disorder exist, [89] including the Bipolar spectrum diagnostic scale , Mood Disorder Questionnaire , the General Behavior Inventory and the Hypomania Checklist. These disorders include schizophrenia , major depressive disorder, [91] attention deficit hyperactivity disorder ADHD , and certain personality disorders, such as borderline personality disorder.
Neurologic diseases such as multiple sclerosis , complex partial seizures , strokes , brain tumors, Wilson's disease , traumatic brain injury , Huntington's disease , and complex migraines can mimic features of bipolar disorder. Infectious causes of mania that may appear similar to bipolar mania include herpes encephalitis , HIV , influenza , or neurosyphilis. The DSM-5 lists three specific subtypes: At least one manic episode is necessary to make the diagnosis; [98] depressive episodes are common in the vast majority of cases with bipolar disorder I, but are unnecessary for the diagnosis.
No manic episodes and one or more hypomanic episodes and one or more major depressive episode. A history of hypomanic episodes with periods of depression that do not meet criteria for major depressive episodes. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: A comparison of lithium and T 3 augmentation following two failed medication treatments for depression: Use of treatment algorithms for depression.
Medication augmentation after the failure of SSRIs for depression. N Engl J Med. Depression and folate status in the US Population. Biomarkers of folate and vitamin B12 are related in blood and cerebrospinal fluid.
The biology of folate in depression: Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 1: Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 2: Coppen A, Bailey J.
Enhancement of the antidepressant action of fluoxetine by folic acid: Folic acid enhances lithium prophylaxis. Red cell folate concentrations in psychiatric patients.
Folate deficiency in depressive illness. Neuroscientific Basis and Practical Applications. Cambridge University Press; Novel therapies for depression: Bolander-Gouaille C, Bottiglieri T. Clinical impact of enzyme defects. Homocysteine Related Vitamins and Neuropsychiatric Disorders.
New York, NY; Springer: CT polymorphism in methylenetetrahydrofolate reductase gene and psychosis variant. Homocysteine as well as methylenetertrahydrofoalte reductase polymorphism are associated with affective psychosis. Enhancement of recovery from psychiatric illness by methylfolate. An open trial of methyltetrahydrofolate in elderly depressed patients. Is methylfolate effective in relieving major depression in chronic alcoholics? A hypothesis of treatment. Curr Ther Res Clin Exp. Folinic acid as an adjunctive treatment for SSRI-refractory depression.
Ann Clin Psych Prevalence and effects of gene-gene and gene-nutrient interactions on serum folate and serum total homocysteine concentrations in the US: Mindfulness techniques allow patients to step outside themselves and observe emotions without reacting or seeking instant relief through self-harm Dingfelder, The therapist focuses on reducing the most dysfunctional and out-of-control features of the disorder such as suicide attempts or self-injury.
Patients discover alternatives to extreme thoughts and behaviors. Therapist emphasizes developing a good working relationship.
Once destructive behaviors are under control, patients explore the invalidating and traumatic events, as well as their impact on emotional experiencing and processing. Patients start to value themselves and trust their responses versus relying on others to validate them. Cognitive therapy can reduce emotional overload including depression, anxiety, and feelings of being worthless, unlovable, unimportant, etc. These techniques are used with the eating-disordered thinking around body image.
Harmful behaviors cannot be eliminated without having something to put in their place. Constant empathic understanding is vital so that patients can form a healthy bond with you. This is challenging because these patients have a very difficult time getting along with other people, and that will include you. They have poor boundaries and want to take up your time, energy, and interest.
If you let them, they will take advantage of your availability. You must set appropriate limits as to when and how they can contact you out of session. You may initially be idealized where you can do no wrong.
Then when you say or do something that is perceived as abandoning, they turn hostile and you become the devalued object who wounded them. With compassion, listening, boundaries, and exploring their feelings, they can begin to see the projection as a reflection of themselves. With a strong bond, you will be able to work out these impasses. The more severe the personality disorder, the more impulsive and extreme the self-destructive tendencies can be.
Depression is often driven by external circumstances harsh feedback from others, failing at a task, experiencing rejection, etc. They may become so depressed that their sense of reality becomes distorted. Some can have delusions or hallucinations.
When they cannot keep themselves safe, consider hospitalization. Borderline patients will compare you with other treatment team members. They see one person as a good object and the other as a bad object and will try to play one practitioner against the other. Your role is to manage the relationships with all practitioners, including informing them of splitting.
Pay attention to transference and countertransference. You have to be the consistent, stable rock for them to lean on and play out their relationship dramas. Be clear and honest with everything you tell them.
There are occasions when they will be able to hear feedback, and also moments when the most appropriate response is mirroring and empathic understanding. Therapeutic accomplishments are slow and patience is essential. Many of these patients never fully recover from their eating disorder, struggling with some aspect of it for the rest of their lives.
If their physical health is stable, they can continue in outpatient therapy long-term. Holly, a year-old bulimic, entered therapy after the breakup of a serious relationship.
She refused to see a psychiatrist for a medications consultation. She was taking Lexapro prescribed by her female physician, whom Holly had known for years and trusted. Holly was suicidal, but had no concrete plan. She was so distraught that she was bingeing uncontrollably and vomiting during the day and then getting drunk with friends at night. She only drank to excess whenever she thought she was going to be, or actually was rejected, by her boyfriend.
At work the next day, she would pull it together masking that she felt out of sorts. The children at the daycare center where she worked never seemed to notice her fatigue or depression. She talked about a series of relationships in which things would be going well and then she would freak out that the boyfriend might leave.
In therapy, she watched for signs of disapproval — a look, a gesture, a tone. If she perceived criticism, she would withdraw and not talk, saying she wanted to go home. She left therapy early, only to call that evening or a day later, asking to talk about what happened and what was said or done to offend her.
She also called every weekend when she was drunk and threatened suicide. Building boundaries and clear guidelines for contact became an important therapeutic goal. At the same time, Holly was encouraged to step outside herself and observe what was happening that had stirred such powerful emotions, then pull back from reacting to let the emotions dissipate. While working with the borderline personality symptoms, the eating disorder and substance abuse symptoms were also addressed.
Holly felt so flooded by feelings that food and alcohol were the quickest ways to make feelings bearable. Purging not only prevented weight gain, but also served as punishment for being unlovable. If her weight went up, she berated herself, which created intensely dysphoric moods.
A dietician designed meal plans to foster structure and predictability. Part of every session was reserved to discuss the struggles with bingeing and purging. Particular emphasis was placed on three meals to reduce bingeing from hunger. She had to call her best friend, write down her feelings she had been a literature major in college , or get herself out of the house if she thought she might binge or purge.
It took Holly more than two years to make significant changes in food habits, such as going to the grocery store weekly and eating meals regularly. Her purging was cut in half. For a couple of years, Holly continued her pattern of dating, breaking up, and becoming suicidal until she met a patient and unique man. She would not bait him into a fight.
Instead, she would tell him she would talk to him later and deal with her feelings on her own. She began by looking at the fact that he showed her loving, caring behaviors. Holly went through her emotions and then called him back when she was calmer. She made conscious attempts to stay at home instead of drinking with friends.
Sometimes she was successful and sometimes she gave in and partied. Then she reminded herself that she easily feels abandoned. Her father was in the military and often deployed. When he was in town, he hung out with his buddies. Her excessive drinking became less frequent, as did her relationship sabotaging behaviors.
She even admitted that she was handling her emotions better. She still claimed not to trust her therapist and may never do so, although she continues therapy. A pervasive and excessive need to be taken care of that leads to submissive and clinging behavior and fears of separation, beginning by early adulthood and present in a variety of contexts as indicated by five or more of the following: Has difficulty making everyday decisions without an excessive amount of advice and reassurance from others Needs others to assume responsibility for most major areas of her life Has difficulty expressing disagreement with others because of fear of loss of support or approval Note: Do not include realistic fears of retribution Has difficulty initiating projects or doing things on his or her own because of lack of self-confidence in judgment or abilities rather than a lack of motivation or energy Goes to excessive lengths to obtain nurturance and support from others, to the point of volunteering to do things that are unpleasant Feels uncomfortable or helpless when alone because of exaggerated fears of being unable to care for himself or herself Urgently seeks another relationship as a source of care and support when a close relationship ends Is unrealistically preoccupied with fears of being left to take care of himself or herself Dependent Personality Disorder and Eating Disorders: Individuals with dependent personality disorder have a pervasive need to cling to people who have stronger personalities and who will make a wide range of decisions for them.
They have little initiative and are rather naive. They have successfully found a way to elicit a desired relationship, even if the cost is their own expression of themselves. I believe [clinicians] should ask patients and their families whether there is a family history of bipolar disorder or psychosis before prescribing these medications. Most patients and their families don't know the answer when they are first asked, so time should be allowed for the patient to ask family or relatives, between the session when asked by [the clinician] and a follow-up session.
This may increase the wait for a medication slightly, but because some patients are vulnerable, this is a necessary step for [the clinician] to take.
I believe that psychiatry as a field has not emphasized this point sufficiently. As a result, some patients have been harmed by the very treatments that were supposed to help them; or to the disgrace of psychiatry, harmed and then misdiagnosed. Both substance- and medication-induced psychosis can be excluded to a high level of certainty while the person is psychotic, typically in an emergency department, using both a Broad spectrum urine toxicology screening, and a Full serum toxicology screening of the blood.
Some dietary supplements may also induce psychosis or mania, but cannot be ruled out with laboratory tests. So a psychotic person's family, partner, or friends should be asked whether he or she is currently taking any dietary supplements.
Only after these relevant and known causes of psychosis have been ruled out can a psychiatric differential diagnosis be made. A mental health clinician will incorporate family history, observation of a psychotic person's behavior while the person is experiencing active symptoms, to begin a psychiatric differential diagnosis.
Diagnosis also includes self-reported experiences, as well as behavioral abnormalities reported by family members, friends, or significant others. Mistakes in this stage include: Not screening for dissociative disorders.
Dissociative identity disorder and psychotic symptoms in schizoaffective disorder have considerable overlap, yet a different overall treatment approach. Some people get drunk to feel good temporarily and the hang over is the least of their problems. Some people take anti-depressants like SSRIs which are addictive and bad for one's health. Some people try to have very healthy lifestyles and eat organic foods to achieve a feeling of wellbeing and being 'wired' and 'on a buzz' all the time, but never quite reach that feeling.
Some people rely on religious experience and participation in religious events to feel good this is not to say that they are not valid and beneficial activities in themselves, good in absolute terms. Some people have to play music constantly in order to feel slightly better, but this is tiring and when the music stops Some people are workaholics. Some people have to take regular baths to feel relaxed and good. Some people are addicted to watching television or watching movies.
Some people rely on having as much sex as possible to feel good, which is partly dependant on their 'ability to deliver the goods'. Some people rely on over-eating or comfort foods like chocolate to feel good and release endorphins. Some people take part in charity work.
Wanting to feel good, to be distracted from one's normal state of mind or experience a new state of mind is something that unites everyone in the world! However, as is frequently the case, people may want similar things, but the 'means' of getting them divides people. The irony is that none of the above strategies are likely to be entirely successful in getting the person what he wants. It is only when we address the core issue of hormonal dysfunction that we can actually feel good virtually all the time.
Recreational drugs, legal and illegal, work by temporarily disrupting neurotransmitter activity or by mimmicking neurotransmitters. If they didn't do this, they wouldn't be drugs, they wouldn't 'work' and people wouldn't take them!
Taking drugs damages your internal organs and aforementioned glands to varying degrees, toxifies your body and disrupts your endocrine system, actually lowering your normal serotonin production, and frequently increasing present psychological problems and inducing new ones which result in decreased serotonin production again.
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