The amoxicillin in this combination medication can commonly cause a mild rash that is usually not serious. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe allergic reaction.
Therefore, seek immediate medical attention if you develop any rash. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US -Call your doctor for medical advice about side effects. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at Quick GuideSymptoms of Mono: This medication should not be used if you have certain medical conditions.
Before using this medicine, consult your doctor or pharmacist if you have: Before using this medication, tell your doctor or pharmacist your medical history, especially of: Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be more sensitive to this drug. This medication should be used only when clearly needed during pregnancy.
Caution is advised if this medication is given before delivery for a certain condition premature rupture of fetal membranes due to a possible increased risk of harm to the newborn.
Discuss the risks and benefits with your doctor. This medication passes into breast milk. The histologic findings on liver biopsy have consisted of predominantly cholestatic, treatment. The histologic findings on liver biopsy have consisted of predominantly cholestatic, hepatocellular, or mixed cholestatic hepatocellular changes.
The hepatic dysfunction, which may be severe, is usually reversible. Deaths have been reported. These reactions are usually reversible on discontinuation of therapy and are believed to be hypersensitivity phenomena. Miscellaneous Tooth discoloration brown, yellow, or gray staining has been reported.
Most reports occurred in pediatric patients. Discoloration was reduced or eliminated with brushing or dental cleaning in most cases. Coadministration of probenecid is not recommended. Oral Anticoagulants Abnormal prolongation of prothrombin time increased international normalized ratio [INR] has been reported in patients receiving amoxicillin and oral anticoagulants. Adjustments in the dose of oral anticoagulants may be necessary to maintain the desired level of anticoagulation.
Allopurinol The concurrent administration of allopurinol and amoxicillin increases the incidence of rashes in patients receiving both drugs as compared to patients receiving amoxicillin alone. It is not known whether this potentiation of amoxicillin rashes is due to allopurinol or the hyperuricemia present in these patients.
Following administration of amoxicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted. Before initiating therapy with AUGMENTIN, careful inquiry should be made regarding previous hypersensitivity reactions to penicillins, cephalosporins, or other allergens. Hepatic toxicity is usually reversible; however, deaths have been reported.
Hepatic function should be monitored at regular intervals in patients with hepatic impairment. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C.
Hypertoxinproducing strains of C. CDAD must be considered in all patients who present with diarrhea following antibacterial use. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients.
There are no data with Amoxicillin and Clavulanate Potassium Tablets and allopurinol administered concurrently. In common with other broad-spectrum antibiotics, Amoxicillin and Clavulanate Potassium Tablets may reduce the efficacy of oral contraceptives.
Following administration of ampicillin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone and estradiol has been noted. This effect may also occur with amoxicillin and therefore Amoxicillin and Clavulanate Potassium Tablets.
Information for patients Patients should be counseled that antibacterial drugs including Amoxicillin and Clavulanate Potassium Tablets, should only be used to treat bacterial infections. They do not treat viral infections e. When Amoxicillin and Clavulanate Potassium Tablets are prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed.
Skipping doses or not completing the full course of therapy may: Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued.
Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools with or without stomach cramps and fever even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible. Labor and Delivery Oral ampicillin-class antibiotics are generally poorly absorbed during labor.
Studies in guinea pigs have shown that intravenous administration of ampicillin decreased the uterine tone, frequency of contractions, height of contractions, and duration of contractions; however, it is not known whether the use of Amoxicillin and Clavulanate Potassium Tablets in humans during labor or delivery has immediate or delayed adverse effects on the fetus, prolongs the duration of labor, or increases the likelihood that forceps delivery or other obstetrical intervention or resuscitation of the newborn will be necessary.
In a single study in women with premature rupture of fetal membranes, it was reported that prophylactic treatment with Amoxicillin and Clavulanate Potassium Tablets may be associated with an increased risk of necrotizing enterocolitis in neonates. Nursing Mothers Ampicillin-class antibiotics are excreted in the milk; therefore, caution should be exercised when Amoxicillin and Clavulanate Potassium Tablets are administered to a nursing woman.
Safety and effectiveness of Amoxicillin and Clavulanate Potassium Tablets in pediatric patients weighing less than 40 kg have not been established. Geriatric use An analysis of clinical studies of Amoxicillin and Clavulanate Potassium Tablets was conducted to determine whether subjects aged 65 and over respond differently from younger subjects. This analysis and other reported clinical experience have not identified differences in responses between the elderly and younger patients, but a greater sensitivity of some older individuals cannot be ruled out.
This drug is known to be substantially excreted by the kidney, and the risk of dose dependant toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.
The overall incidence of side effects, and in particular diarrhea, increased with the higher recommended dose. Other less frequently reported reactions include: Abdominal discomfort, flatulence, and headache.
The following adverse reactions have been reported for ampicillin-class antibiotics: Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment. Skin rashes, pruritus, urticaria, angioedema, serum sickness-like reactions urticaria or skin rash accompanied by arthritis, arthralgia, myalgia, and frequently fever , erythema multiforme rarely Stevens-Johnson syndrome , acute generalized exanthematous pustulosis, hypersensitivity vasculitis, and an occasional case of exfoliative dermatitis including toxic epidermal necrolysis have been reported.
These reactions may be controlled with antihistamines and, if necessary, systemic corticosteroids.
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