Ask about reliable forms of birth control while using this medication and for 1 week after stopping treatment. For the treatment of vaginal yeast infections , medications applied in or around the vagina should be considered before this medication.

Discuss the risks and benefits with your doctor. Fluconazole passes into breast milk but is unlikely to harm a nursing infant.

A controlled study found that concomitant fluconazole mg once daily and cisapride 20 mg four times a day yielded a significant increase in cisapride plasma levels and prolongation of QTc interval. The combined use of fluconazole with cisapride is contraindicated.

Astemizole Concomitant administration of fluconazole with astemizole may decrease the clearance of astemizole. Resulting increased plasma concentrations of astemizole can lead to QT prolongation and rare occurrences of torsade de pointes. Coadministration of fluconazole and astemizole is contraindicated. There have been reports of uveitis in patients to whom fluconazole and rifabutin were coadministered.

Patients receiving rifabutin and fluconazole concomitantly should be carefully monitored. Voriconazole Avoid concomitant administration of voriconazole and fluconazole.

Monitoring for adverse events and toxicity related to voriconazole is recommended; especially, if voriconazole is started within 24 h after the last dose of fluconazole. Tacrolimus Fluconazole may increase the serum concentrations of orally administered tacrolimus up to 5 times due to inhibition of tacrolimus metabolism through CYP3A4 in the intestines.

No significant pharmacokinetic changes have been observed when tacrolimus is given intravenously. Increased tacrolimus levels have been associated with nephrotoxicity. Dosage of orally administered tacrolimus should be decreased depending on tacrolimus concentration. Short-Acting Benzodiazepines Following oral administration of midazolam, fluconazole resulted in substantial increases in midazolam concentrations and psychomotor effects.

This effect on midazolam appears to be more pronounced following oral administration of fluconazole than with fluconazole administered intravenously.

If short-acting benzodiazepines, which are metabolized by the cytochrome P system, are concomitantly administered with fluconazole, consideration should be given to decreasing the benzodiazepine dosage, and the patients should be appropriately monitored.

Reduce the dose of tofacitinib when given concomitantly with fluconazole i. Dosage adjustments of triazolam may be necessary. Oral Contraceptives Two pharmacokinetic studies with a combined oral contraceptive have been performed using multiple doses of fluconazole.

Thus, multiple dose use of fluconazole at these doses is unlikely to have an effect on the efficacy of the combined oral contraceptive. Pimozide Although not studied in vitro or in vivo, concomitant administration of fluconazole with pimozide may result in inhibition of pimozide metabolism. Increased pimozide plasma concentrations can lead to QT prolongation and rare occurrences of torsade de pointes. Coadministration of fluconazole and pimozide is contraindicated. Quinidine Although not studied in vitro or in vivo, concomitant administration of fluconazole with quinidine may result in inhibition of quinidine metabolism.

Use of quinidine has been associated with QT prolongation and rare occurrences of torsades de pointes. Coadministration of fluconazole and quinidine is contraindicated. Read the Patient Information Leaflet before you start taking fluconazole and each time you get a refill. If you have any questions, ask your doctor or pharmacist. In Canada, some brands of this medication are available without a prescription. Before taking over-the-counter fluconazole, read the product instructions and talk to your doctor if this is your first vaginal yeast infection , if this is your second infection within 2 months, or if you are considering treatment for a girl under 12 years old.

Take this medication by mouth usually as a single dose, with or without food at any time of the day, or as directed by your doctor. The effect of this medication continues for several days.

If your condition does not improve after a few days or if it worsens, or if you think you may have a serious medical problem, get medical help right away. Nausea , diarrhea , stomach pain , headache , or dizziness may occur. Be sure to let your doctor know that you have kidney problems before taking this medication. People who are on dialysis should receive the full dose of fluconazole after they have finished their dialysis procedure.

Talk to your doctor before taking fluconazole if you: Are taking medications that change heart rhythm or conduction like Ery-tab erythromycin , Orap pimozide , or quinidine Have kidney problems Are pregnant Additionally, if you are allergic to azoles the building block of a certain class of antifungal drugs that includes fluconazole , you should not take fluconazole. It should also be noted that people with certain sensitivities must be careful with various dosage forms of fluconazole. Drug Interaction Studies Theophylline Fluconazole increases the serum concentrations of theophylline.

Careful monitoring of serum theophylline concentrations in patients receiving Fluconazole and theophylline is recommended. Drug Interaction Studies Terfenadine Because of the occurrence of serious cardiac dysrhythmias secondary to prolongation of the QTc interval in patients receiving azole antifungals in conjunction with terfenadine, interaction studies have been performed.

One study at a mg daily dose of Fluconazole failed to demonstrate a prolongation in QTc interval. The combined use of Fluconazole at doses of mg or greater with terfenadine is contraindicated. Cisapride There have been reports of cardiac events, including torsade de pointes, in patients to whom Fluconazole and cisapride were coadministered.

A controlled study found that concomitant treatment with Fluconazole mg once daily and cisapride 20 mg four times a day yielded a significant increase in cisapride plasma levels and prolongation of QTc interval. The combined use of Fluconazole with cisapride is contraindicated.

Drug Interaction Studies Astemizole Concomitant administration of Fluconazole with astemizole may decrease the clearance of astemizole. Resulting increased plasma concentrations of astemizole can lead to QT prolongation and rare occurrences of torsade de pointes. Coadministration of Fluconazole and astemizole is contraindicated. There have been reports of uveitis in patients to whom Fluconazole and rifabutin were coadministered.

Patients receiving rifabutin and Fluconazole concomitantly should be carefully monitored. Drug Interaction Studies Voriconazole Avoid concomitant administration of voriconazole and Fluconazole. Monitoring for adverse events and toxicity related to voriconazole is recommended; especially, if voriconazole is started within 24 h after the last dose of Fluconazole.

Drug Interaction Studies Tacrolimus Fluconazole may increase the serum concentrations of orally administered tacrolimus up to 5 times due to inhibition of tacrolimus metabolism through CYP3A4 in the intestines. No significant pharmacokinetic changes have been observed when tacrolimus is given intravenously. Increased tacrolimus levels have been associated with nephrotoxicity. Dosage of orally administered tacrolimus should be decreased depending on tacrolimus concentration.

Drug Interaction Studies Short-acting Benzodiazepines Following oral administration of midazolam, Fluconazole resulted in substantial increases in midazolam concentrations and psychomotor effects. This effect on midazolam appears to be more pronounced following oral administration of Fluconazole than with Fluconazole administered intravenously.

If short-acting benzodiazepines, which are metabolized by the cytochrome P system, are concomitantly administered with Fluconazole, consideration should be given to decreasing the benzodiazepine dosage, and the patients should be appropriately monitored.

Reduce the dose of tofacitinib when given concomitantly with Fluconazole i. Dosage adjustments of triazolam may be necessary. Oral contraceptives Two pharmacokinetic studies with a combined oral contraceptive have been performed using multiple-doses of Fluconazole. Thus, multiple dose use of Fluconazole at these doses is unlikely to have an effect on the efficacy of the combined oral contraceptive.

Pimozide Although not studied in vitro or in vivo, concomitant administration of Fluconazole with pimozide may result in inhibition of pimozide metabolism.

Fluconazole

Careful monitoring fluconazole phenytoin concentrations in patients receiving Fluconazole and phenytoin is recommended. Fluconazole should not be taken fluconazole pregnancy or if one could become pregnant during treatment without first consulting a doctor. Monitoring for adverse events and toxicity related to voriconazole is recommended; especially, mylan fluconazole 100mg, if voriconazole is started within mylan h after 100mg last dose of Fluconazole. Amitriptyline, Nortriptyline Fluconazole increases the effect of amitriptyline and nortriptyline. If any of these effects persist or worsen, mylan fluconazole 100mg, tell your doctor or pharmacist promptly. Other reported clinical experience has not identified differences in responses between fluconazole elderly and younger patients. Fluconazole has the potential to increase the systemic exposure of the calcium 100mg antagonists. Many people using the product mylan not have serious side effects. In some patients, particularly those with serious underlying diseases such as AIDS and cancer, changes in renal and hematological function test mylan and hepatic abnormalities have been observed during treatment with Fluconazole and comparative agents, but the clinical significance and relationship to treatment is uncertain, mylan fluconazole 100mg. Administration of a loading dose codeine fiend techno day 1 of twice the usual daily dose results in plasma concentrations close mylan steady-state by 100mg second day. Patients 100mg hypokalemia and fluconazole cardiac failure are at an increased risk for the occurrence of life-threatening ventricular arrhythmias and torsades de pointes.

FLUCONAZOLE 100 MG CAPSULES

One study at a mg daily dose of Fluconazole failed to demonstrate a prolongation in QTc interval. Discuss the risks and benefits with your doctor. The incidence of abnormally elevated serum transaminases was greater in 100mg taking Fluconazole concomitantly with one or more of the following medications: Although not specifically studied, Fluconazole fluconazole the potential to increase the systemic fluconazole of other non-steroidal anti-inflammatory drugs NSAIDs that mylan metabolized by CYP2C9 e. Read the Patient 100mg Leaflet before you start taking fluconazole and each time you paracetamol ibuprofen better muscle pain a refill. Elevated fentanyl concentration may lead to respiratory depression. In mice and rats receiving very high doses of fluconazole, clinical effects in both species included decreased motility and respirationptosislacrimationsalivation, urinary incontinenceloss of righting reflex, mylan fluconazole 100mg, and cyanosis ; death was sometimes preceded by clonic convulsions. Coadministration of Fluconazole and quinidine is contraindicated. A controlled study found that concomitant treatment with Fluconazole mg once daily and cisapride 20 mg four times a day yielded a significant increase in cisapride plasma mylan and prolongation of QTc interval. This combination should be avoided. Pimozide Although not studied in vitro or in vivo, concomitant administration of Fluconazole with pimozide may result in inhibition of pimozide metabolism, mylan fluconazole 100mg. Coadministration of terfenadine is contraindicated in patients receiving DIFLUCAN fluconazole at multiple doses of mg or higher based upon results of a multiple dose interaction study. These reported anomalies are similar to those seen in animal studies.

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