How long should I take each of my medicines? What happens if I miss a dose? How can I remember to take all of these medicines? Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
Questions About Daily Living When can I start my normal activities again for example, going back to work, walking, dancing, playing golf, having sex, working in the garden, taking care of children or grandchildren? Are there any activities I should not do? Are there any foods I need to stay away from? Plavix for oral administration is provided as either pink, round, biconvex, debossed, film-coated tablets containing Each tablet contains hydrogenated castor oil, hydroxypropyl cellulose, mannitol, microcrystalline cellulose and polyethylene glycol as inactive ingredients.
The pink film coating contains ferric oxide, hypromellose , lactose monohydrate, titanium dioxide and triacetin. The tablets are polished with Carnauba wax. Plavix - Clinical Pharmacology Mechanism of Action Clopidogrel is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets. Pharmacodynamics Clopidogrel must be metabolized by CYP enzymes to produce the active metabolite that inhibits platelet aggregation.
This action is irreversible. Consequently, platelets exposed to clopidogrel's active metabolite are affected for the remainder of their lifespan about 7 to 10 days.
Platelet aggregation induced by agonists other than ADP is also inhibited by blocking the amplification of platelet activation by released ADP. Dose-dependent inhibition of platelet aggregation can be seen 2 hours after single oral doses of Plavix. Repeated doses of 75 mg Plavix per day inhibit ADP-induced platelet aggregation on the first day, and inhibition reaches steady state between Day 3 and Day 7. Platelet aggregation and bleeding time gradually return to baseline values after treatment is discontinued, generally in about 5 days.
Hepatically Impaired Patients After repeated doses of 75 mg Plavix per day for 10 days in patients with severe hepatic impairment, inhibition of ADP-induced platelet aggregation was similar to that observed in healthy subjects. Gender In a small study comparing men and women, less inhibition of ADP-induced platelet aggregation was observed in women. Since both have a 75 mg dosage form, prescriptions can more easily be misread, especially when prescriptions are handwritten and may not be clearly interpreted by the pharmacist.
Plavix stops blood platelets from sticking together and forming a clot. This makes it useful for lowering the risk of heart disease and stroke caused by blood clots. Aspirin also works similarly but Plavix is one of the newer antiplatelet drugs that doctors often use for this purpose. Avoid concomitant use of repaglinide with Plavix. If concomitant use cannot be avoided, initiate repaglinide at 0.
Increased frequency of glucose monitoring may be required during concomitant use. Inhibition of platelet aggregation by clopidogrel is achieved through an active metabolite.
The metabolism of clopidogrel can also be impaired by drugs that inhibit CYP2C19, such as omeprazole or esomeprazole. Thienopyridines inhibit platelet aggregation for the lifetime of the platelet days.
Because the half-life of clopidogrel's active metabolite is short, it may be possible to restore hemostasis by administering exogenous platelets; however, platelet transfusions within 4 hours of the loading dose or 2 hours of the maintenance dose may be less effective. Discontinuation Of Plavix Discontinuation of Plavix increases the risk of cardiovascular events. If Plavix must be temporarily discontinued e. When possible, interrupt therapy with Plavix for five days prior to such surgery.
Telmisartan 40 1 8. I will stop Nitrocontin for 24 hrs. Sir ,I want your advice on this. Read More The most widely studied and prescribed antiplatelet agent for the prevention of stroke and other serious vascular events among high vascular risk patients is aspirin.
I take aspirin daily prior to CHF.. Plavix and aspirin for preventing stroke and other serious vascular events in high vascular risk patients. Up to one year after a stent implant, plavix and aspirin are the recommended protocol as statistics have shown a high risk for clot. Read More I was a healthy woman at I walked for an hour daily and practiced yoga for the last 35 years.
Considering a check up, I went to hospital emergency. Hepatically Impaired Patients After repeated doses of 75 mg Plavix per day for 10 days in patients with severe hepatic impairment, inhibition of ADP-induced platelet aggregation was similar to that observed in healthy subjects.
Gender In a small study comparing men and women, less inhibition of ADP-induced platelet aggregation was observed in women. Absorption After single and repeated oral doses of 75 mg per day, clopidogrel is rapidly absorbed. Effect of food Plavix can be administered with or without food. Similar results were observed when a Plavix mg loading dose was administered with a high-fat breakfast. Metabolism Clopidogrel is extensively metabolized by two main metabolic pathways:
Read More I am 50yr old male. Plavix and aspirin for preventing stroke and daily serious vascular events in high vascular risk patients. These guidelines also recommend that prescription oral antiplatelet plavix, like BRILINTA, in addition to low-dose aspirin, be taken for at least the first 12 months after a heart attack. Instances of serious bleeding, such as internal bleeding, may require blood transfusions or surgery. It also dissolves freely in methanol, dissolves sparingly in methylene chloride, and is practically insoluble in ethyl ether. Gender In a small study comparing men and women, less inhibition of ADP-induced platelet aggregation was observed in women. It cannot be ruled out that a trial with a different design would demonstrate a clinical benefit in this twice population. Patients also took other medications commonly prescribed after a heart attack. Cilostazol is contraindicated in patients with known or suspected hypersensitivity to any of its components. Plavix is also available in the US. The mechanism of the effects of cilostazol tablets on the symptoms of intermittent claudication is not fully understood. Avoid concomitant use of repaglinide with Plavix. Cilostazol inhibits platelet aggregation in a reversible manner. Opioids As with other oral P2Y12 inhibitors, coadministration of opioid agonists delay and reduce the absorption of clopidogrel, given because of slowed gastric emptying, resulting in reduced exposure to its metabolites [see Clinical Clozapine tachycardia treatment
Tags: nexium card canada medical abortion mifeprex misoprostol t�c dỴng thuốc misoprostol stada
© Copyright 2017 Plavix given twice daily. Plavix official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more..